Labour MP Pat Glass has resigned as shadow education secretary just two days after being appointed to the role.
She tweeted: "It is with a heavy heart that I have today resigned. My dream job but the situation is untenable."Ms Glass was joined by Emma Lewell-Buck who said she was "heartbroken at the state of the party" and could no longer continue as shadow local government minister.
David Cameron joined the calls for Mr Corbyn to resign during Prime Minister's Questions in the Commons, saying it was "not in Britain's interests" for him to stay in the job.
Despite the no confidence vote Mr Corbyn is refusing to quit, insisting he would not "betray" the 60% of members and supporters who backed him to succeed Ed Miliband.
Angela Eagle - the most senior member of the shadow cabinet to join the mass mutiny - is widely tipped to
be chosen to take him on in a leadership contest.
Dame Tessa Jowell told Mr Corbyn it was "absolutely clear that your continued leadership is putting the Labour Party's future in jeopardy and denying millions of people in our country who so desperately need representation by a Labour government".
Former deputy leader Harriet Harman said Mr Corbyn had "no right or mandate" to stay in office.
In a strongly-worded appeal to him to go, she said: "Jeremy earned the right to take up the leadership of the party with a big majority. But he has failed and he has no right or mandate to stay in office.
"If Jeremy goes now, he will earn the respect and admiration of the party. If he stays, he will be responsible for damage to the party on the gravest scale."
Shadow chancellor John McDonnell conceded there might be a leadership contest and urged MPs to "play by the rules" and "respect the decisions of our members".
He will be joined by Public and Commercial Services union chief Mark Serwotka and Fire Brigades Union general secretary Matt Wrack, who will speak in support of him.
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